MOCA Cannabis Education



Cannabinoids are variety of chemical compounds that bind to special receptors in the endocannabinoid system. This process is widely recognized as the “key and lock” process because the human body has specific binding sites (“locks”) on the surface of many cell types and the body produces endocannabinoids (“keys”) which bind to these cannabinoid receptors to activate or “unlock” them.

Endocannabinoid System

An Endogenous Cannabinoid System (ECS) is commonly referred to as the endocannabinoid system which is found in every animal and regulates a broad range of biological functions and works as a biochemical control system of neuromodulatory lipids. Neuromodulatory lipids are molecules that include fats, waxes, sterols, and fat-soluble vitamins such as vitamins A, D, E, K, and a variety of others. Specialized receptors and compounds interact like a key and lock where specialized receptors will only accept specific classes of compounds and will be unaffected by other compounds. Specialized receptors are located throughout the entire body and can be found in the hippocampus, cerebral cortex, the cerebellum, putamen, hypothalamus, amygdala, and more. When a specific cannabinoid or combination of cannabinoids bind to a specialized receptor an event is triggered within a cell which results in a change of cell’s activity. This change of activity causes the gene regulation and/or the signals that it sends to neighboring cells, this process is called “signal transduction.”

Types of Cannabinoids

cbd moca button    Cannabidiol (CBD)

CBD is very valuable for its tremendous medicinal possibilities. When CBD and THC are combined properly many medical conditions can be treated. CBD acts as an antagonist for both CB1 and CB2 receptors and has a low binding affinity for both. The low binding affinity for both suggests that CBD’s mechanism of action is mediated by other receptors in the brain and body

thc moca button    Tetetrahydrocannabinol (THC)

THC is typically the most abundant cannabinoid present in cannabis products. THC is responsible for the psychoactive effects experienced when consuming cannabis. When cannabis is smoked or otherwise ingested, THC travels into the bloodstream and eventually binds to cannabinoid receptors throughout your body. The receptors that THC binds with affect a person’s pleasure, appetite coordination, memory, concentration, sensory and time perception, and a variety of other important functions. Possible side effects of larger doses of THC may include anxiety, elation, burning eyes, dry mouth, shaking or trembling, increased heart rate, shortness of breath, and short term memory loss.

thca moca button    Tetrahydrocannabinolic Acid (THCA)

THCA is the main constituent in raw cannabis and transforms to THC when burned, vaporized, or heated at a certain temperature. Acidic cannabinoids (such as THCA, CBDA, CBGA, etc.) hold the most COX-1 and COX-2 inhibition which contributes to cannabis’ anti-inflammatory effects. THCA also acts as an anti-proliferative and anti-spasmodic.

cbda moca button    Cannabidiolic Acid (CBDA)

CBDA (also known as CBD-acid or CBD-a) is the main form in which CBD exists in the cannabis plant along with THCA (THC-acid). CBD is obtained when compounds are heated and heating or catalyzing CBD-a transforms into CBD which caused an increase in the total CBD level. Research shows that higher concentrations of CBDA displayed pronounced antimicrobial activity than CBD alone.

cbg moca button    Cannabigerol (CBG)

CBG is a non-psychoactive cannabinoid with antibacterial effects that can alter the overall effects of cannabis. It is known to kill or slow bacterial growth, reduce inflammation, inhibit cell growth in tumor and cancer cells, and promote bone growth. It also acts as a low-affinity antagonist at the CB1 receptor. As of now, the CBG pharmacological activity at the CB2 receptor is currently unknown.

cbn moca button    Cannabinol (CBN)

CBN is a cannabinoid that is mildly psychoactive and is produced from the degradation of THC. CBN acts as a weak agonist at both the CB1 and CB2 receptors, with greater affinity for CB2 receptors than CB1. There is usually very little or no CBN in a fresh plant and the degradation of THC into CBN is often described as creating the sedative effect known as “couch lock.”

cbc moca button    Cannabichromene (CBC)

Research and studies show that CBC along with cannabidiol (CBD) and tetrahydrocannabinol (THC) have antidepressant effect. CBC alone is suggested to play a role in the anti-inflammatory and anti-viral effects of cannabis, contribute to the overall analgesic effects of medical cannabis, and may also help promote neurogenesis.

cbdv moca button    Cannabidivarin (CBDV)

Research on CBDV is still in its initial stages but research has shown promise for its use in the management of epilepsy. Its hope for epilepsy is due to its action at TRPV1 receptors and modulation of gene expression.

thcv moca button    Tetrahydrocannabivarin (THCV)

THCV is a minor cannabinoid found in only some strains or cannabis and the only structural difference between THCV and THC is the presence of a propyl (3 carbon) group, rather than a pentyl (5 carbon) group, on the molecule. This small variation causes THCV to produce very different effects than THC. Such effects include a reduction in panic attacks, suppression of appetite, and the promotion of bone growth.

Cannabinoid Receptors

Primary cannabinoid receptors are identified as Cannabinoid type 1 receptors (CB-R) and Cannabinoid type 2 receptors (CB2-R). These receptors can be “unlocked” by three kinds cannabinoids:

  1. Endocannabinoids – endogenous-fatty-acid cannabinoids produced naturally in the body. (e.g., anadaminde and 2-AG)
  2. Phytocannabinoids – concentrated in the oily resin of the buds and leaves of plants such as cannabis (e.g., THC and CBD)
  3. Synthetic cannabinoids – manufactured by artificial means such as in a laboratory

cannabinoids effects

CB1-R was first detected in the brain and studies now show that it is found many other organs, connective tissues, gonads and glands. CB1-R play an important role in the coordination of movements, spatial orientation, cognitive performance and motivation and sensory perceptions such as taste, touch, smell, and hearing.

The most important function of the CB1-R is the reduction of excessive or inadequate signaling by the neurotransmitters in the brain. When CB1-R is activated the hyperactivity of the messengers is regulated back into balance. Simply, when THC binds to BC1-R activity in the pain circuits in inhibited which results in a reduction of pain. Symptoms such as nausea, muscle spasticity and seizures can be either alleviated or diminished with cannabinoid therapy.

CB2-R are associated with the immune system and found outside of the brain in places such as the gut, spleen, liver, heart, kidneys, bones, blood vessels, lymph cells, endocrine glands and reproductive organs. Studies show that CB2-R plays an important role in the signal processing of the brain.

The TRPV1(transient receptor potential vanilloid-type one) is a receptor which detects and regulates body temperature. It also is responsible for the sensations of extreme external heat and pain and is subject to desensitization. If this receptor is continuously stimulated the pathway will eventually slow down or even stop. This stimulation raises therapeutic possibilities for agents to effectively treat certain kinds of neuropathic pain.

cannabinoids wheel moca

From 1992 to today, research has shown that there are over 200 substances which resemble endocannabinoids and complement their function in what has been termed the “entourage effect.” Several endocannabinoids do not only bind to cannabinoid receptors, but also to a possible CB3 receptor (the GPR55 receptor) to vanilloid receptors and further receptors.

Aside from endocannabinoids, phytocannabinoids have been found in the cannabis plant and have been identified to work to mimic or counteract the effects of some endocannabinoids. Phytocannabinoids and terpenes are manufactured in resin glands (trichomes) present on the flowers and main fan leaves of late-stage cannabis plants. The amount of resin produced and its cannabinoid content varies by plant gender, growing conditions and harvesting time. A cannabinoids chemical stability is affected by temperature, moisture, light and storage, but they will eventually degrade over time in any storage conditions.

A cannabinoid is labeled as an “agonist” when is causes a receptor to act in the same way as it would to a naturally occurring hormone or neurotransmitter. Whereas when a cannabinoid is labeled as an “antagonist” the cannabinoid prevents a receptor from binding to the naturally occurring compound. When a cannabinoid is labeled as an “antagonist”, the resulting event is either altered or diminished. Research is still being conducted to better understand how specific cannabinoids can unlock or lock specific receptors.

Within the cannabis plant there have been over 100 phytocannabinoids that have been identified within the cannabis plant and many have documented medicinal values. Most are the same with just a slight chemical variation making them different from one another. The most commonly known and studied cannabinoids within the cannabis plant are THC which produces the feeling of being “high” and CBD for its healing properties.

Cannabinoids can be taken by a patient by smoking, vaporizing, oral ingestion, transdermal patch, intravenous injection, sublingual absorption or rectal suppository.

Entourage Effect

The entourage effect was introduced as a concept by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam in 1998. Their concept’s focus is that cannabinoids within the cannabis plant work together through a network of coincidental relationships as part of a greater organism and affect the body in a mechanism like the body’s own endocannabinoid system. In short, these compounds work better together than in isolation.

The medicinal superiority of cannabis in comparison to other products containing isolated, single components of the cannabis plant, or synthetic cannabinoids trying to replicate the natural components provokes more research to be conducted to fully understand the medicinal affects that can be found within the cannabis.

Research has shown that THC and CBD when combined give a patient better medicinal aid opposed to them being taken separately. When THC is taken separately and not in proper quantities, there have been reports of THC overdose. Good evidence shows that THC and CBD work together because CBD is known to lock out THC at the CB1-R. When applying the entourage effect, increasing the amount of CBD in the case of a THC overdose will lessen the effects caused by the overdose.

Synthetic cannabinoids have been created, such as Marinol, which are pure synthetic forms of THC. Marinol was introduced in the mid-80’s and it was designed to have the same effect as the cannabis plant as a whole. Upon usage from patients, it was found that patients were not receiving the same affects that came from naturally grown THC. This let researchers to realize that other compounds such as CBD and various terpenes play a larger role than previously realized.

New vs. Old Science

The discovery of the CB1 receptor was in 1988 by Allyn Howlett and Willian Devane. Upon their discovery, CB1 was recognized to have little binding affinity for the CB1 receptor. However, as of today research shows that CBD interacts directly with the CB1 receptor site in ways that are therapeutically relevant. CBD influences how a receptor responds to stimulation by THC and the endogenous cannabinoids. Allosteric modulation of CB1-R changes the conformation (shape) or the receptor, and this can have a dramatic impact on the efficiency of cell signaling.

A positive allosteric modulator that enhances CB1 receptor signaling indicates that CBD could be helpful treating diseases linked to endocannabinoid deficits such as anorexia, migraines, irritable bowel, fibromyalgia, and PTSD. It may also help in treating conditions associated with endocannabinoid excess or over activity, obesity, metabolic disorders, liver disease, cardiovascular issues.